Sunday, May 26, 2013

Type 2 Diabetes , pills not working.Is there option other than insulin ? Maybe

This is an interesting article that opens the door to another treatment option for patients with type 2 diabetes who are considering starting insulin. This study compared the effectiveness of once weekly exenitide 2mg ( GLP-1 Agonist , Bydureon ) to once daily Lantus insulin (Glargine).

Baseline patient characteristic :
                 Bydureon ( exenitide ) 2mg                   Glargine ( Lantus insulin  starting dose 4 units )
 Number              215  patients                                         212 patients          
 Mean age             57                                                          56
 Mean weight       69.9 kg                                                   71 kg
 Mean A1c             8.5                                                           8.5

Results at 26 weeks of treatment :
A1c < 7                 89 of 211 patients ( 42% )                        44 of 210 patients  ( 21% )
A1c <6.5               44 of 214 patients (20.6% )                        9 of 212  patients (4.2 %) 
Weight reduced     yes                                                               no             

 2012 Sep;34(9):1892-908.e1. doi: 10.1016/j.clinthera.2012.07.007. Epub 2012 Aug 9
Efficacy and safety profile of exenatide once weekly compared with insulin once daily in Japanese patients with type 2 diabetes treated with oral antidiabetes drug(s): results from a 26-week, randomized, open-label, parallel-group, multicenter, noninferiority study.

Source

Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Have fun , Be  Smart and discuss all options with your doctor
David Calder, MD

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Your comments and questions are appreciated. David Calder,MD