Define glucose sensitive insulin release.
Beta cells in the pancreas normally respond to any increase in blood glucose levels with an
initial burst of insulin( first phase insulin release that begins with in 2 minutes of food intake)
followed by more sustained insulin release ( second phase insulin release ) as needed to
maintain glucose levels in a normal range.
Type 2 Diabetes:
The decline of insulin sensitivity to increasing glucose levels occurs very early in the
development of type 2 diabetes and is an early marker of Beta cell dysfunction.
Sulfonylureas drugs and meglitinides* stimulate beta cells to release insulin with no
regard for blood glucose levels which increases the risk of hypoglycemia.
Some of the newer medications such as GLP-agonist and DPP-4 inhibitors ** restore
and preserve beta cells ability to release insulin when stimulated by a meal time
increase in glucose levels. This reduces the risk of hypoglycemia.
Sulfonylurea type medications produce a continuous unregulated insulin release
irrespective of a person glucose level and increases the risk of low blood sugars.
GLP-Agonist and DPP-4 inhibitors produce meal stimulated insulin release and
reduce the risk of hypoglycemia
*Amaryl ( glimepiride ) , Glucatrol ( glipizide ) , Diabeta ( glyburide ) and others.
Meglitinides - Starlex (nateglinides ) , Prandin (repaglinide )
** Byetta ( exenatide ) , Victroza ( liraglutide )
Januvia ( sitagliptin ) ,Onglyza ( saxagliptin ) , Tradjenta ( linagliptin ) , Nesina ( alogliptin )
Where is glucagon made and what does it do ? Hint . Click on the link below.
New question - An A1c test result of 8 is equivalent to a mean glucose of_____ .
A little tip for interpreting your A1c results will be revealed tomorrow.
Have fun , Be Smart and reduce your risk of hypoglycemia