Monday, March 18, 2013

Amazing Type 2 Diabetes Medications - Your choice

                           The  better choice is easy 

Glucophage is usually the first medication used used in people with type 2 diabetes allowing the limited insulin production to function more efficiently by reducing insulin resistance.

Choosing a second diabetes medications that deals with  three other dysfunctional  hormones associated with Type 2 Diabetes is a good idea.

There are now 2 classes of medications , DPP-4 Inhibitors and GLP-1 agonist  now available.

                                    DPP-4 inhibitors    
         Januvia ( sitagliptin) , Onglyza (saxagliptin) or Tradjenta (linagliptin)

          These medication inhibit an enzyme that destroys GLP-1 

# 1 allowing the limited amount of GLP-1 found in patients with type 2 diabetes to last longer , 
# 2 stimulating  beta cells in the pancreas to haveglucose sensitive insulin release

# 3 and to also suppresses glucagon  decreasing inappropriate glucose release from the liver

                                     GLP-1 agonist
           Byetta and Bydureon ( exenatide ) and Victroza ( Liraglutide )

    These medications help replace the deficiency of GLP-1 with a twice daily injection ( Byetta ) , once daily injection ( Victroza ) or once weekly injection of Bydureon. These medications provide glucose sensitive insulin release and suppress inappropriate glucagon secretion.  These medications have the added benefit of weight loss allowing existing insulin to work more efficiently.

What is glucose sensitive insulin release ?

Have fun , Be smart and talk to your doctor about these medication
David Calder, MD

I have included some of my previous post on the above subject for your review.

 Glucophage "failed " Now what should I do ?

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Your comments and questions are appreciated. David Calder,MD