Most doctors are concerned about starting metformin in " older people " because of the known deterioration of kidney function with increasing age.
Another problem of getting older is the loss of muscle mass complicating the interpretation of a commonly used test, Creatinine. The test result will be lower and and becomes a less accurate test of kidney function as we age.
This leads to todays topic , the effects of age on kidney function.
A good discussion of the aging kidney was discussed in an article published in ;
Clinical Geriatric Medicine 2009August;25 (3) : 331-358
Acute Kidney Injury in the Elderly
The bad news
Our kidneys lose mass , get smaller and lose function with increasing age
* Kidney mass can decrease by 75 to 80 % by age 80 to 90
* A reduction in blood flow to the kidneys of up to 50% can occur from age 20 to age 80
* Decreased function of our kidney can be observed by age 30 resulting in increased problems
handling salt and water.
A word of caution
Medication dose adjustment may be needed as we get older.
The good news
Despite all of the above , "the kidneys of healthy elderly people are able to compensate and maintain homeostasis under normal conditions". Also 30 % of people do not demonstrate the age related decrease in function.
Have Fun , Be Smart and take care of your body and it will take care of you