Wednesday, October 24, 2012

Triglyceride lowering medication may cause a false positive drug screen


This will be interesting to anyone taking fenofibrate ( Tricor ,Fenoglide ,Lipofen ,Lipidil) . 

This is one of the medications used to help lower triglyceride levels . It may cause a false positive test for amphetamines (Street name  "bennies ")  and Ecstasy  on the routine urine test for drugs.

Have fun , be smart and know your medications side effects. It may keep you out of the slammer.
David Calder,MD


 2012 Oct;34(5):493-5.

False-Positive Amphetamine/Ecstasy (MDMA/3,4-Methylenedioxymethamphetamine) (CEDIA) and Ecstasy (MDMA/3,4-Methylenedioxymethamphetamine) (DRI) Test Results With Fenofibrate.

Source

*Department of Pharmacology, Clinical Pharmacology, and Toxicology Unit, Izmir Katip Celebi University Faculty of Medicine, Ataturk Training and Research Hospital, Izmir, Turkey †Clinic of Psychiatry, Izmir Katip Celebi University Ataturk Training and Research Hospital, Izmir, Turkey ‡Clinical Pharmacology and Toxicology Unit, Izmir Katip Celebi University Ataturk Training and Research Hospital, Izmir Turkey.

Abstract

ABSTRACT:: This case report describes a false-positive amphetamine/ecstasy [3,4-methylenedioxymethamphetamine (MDMA)] and ecstasy (MDMA) screen after therapeutic use of antihyperlipidemic drug, fenofibrate. A 60-year-old male patient was admitted to inpatient psychiatry unit with the diagnosis of alcohol dependency. He was prescribed diazepam 30 mg/day, thiamine 300 mg/day, and naltrexone 50 mg/day. He had also been using fenofibrate 267 mg/day for 3 years for hyperlipidemia and trazodone 100 mg/day for 5 months for insomnia. On routine, urine drugs-of-abuse screening amphetamine/MDMA (CEDIA) test was positive for 4 different occasions and MDMA (DRI) test was positive on 5 different occasions. Gas chromatography/mass spectrometry confirmation of the first positive 3 samples were negative for amphetamine and MDMA. After discontinuation of fenofibrate, amphetamine/MDMA, and MDMA immunoassay results turned out to be negative. Caution should be given to interpretation of amphetamine/MDMA (CEDIA) and MDMA (DRI) tests in patients taking fenofibrate. Specific confirmation with a suitable method should be used to prevent erroneous interpretations.

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Your comments and questions are appreciated. David Calder,MD