It is a game that allows you to be less than perfect and still win
I have a friend who shared his recent laboratory results with me . He has had a coronary bypass and was diagnosed with diabetes at the time of surgery. He currently is taking Lantus insulin ? dose, Novolog about once daily if his sugar is high before a meal, and Januvia. His glucose test result are higher than usual , he does not feel well and has lost weight without trying.
Lab test results
FBS 321 mg/dl
Cholesterol 271 mg/dl
LDL Cholesterol 160 mg/dl
Triglycerides 383 mg/dl
He does not like the idea of multiple injection and will be starting Bydureon if it is approved by his insurance company and his doctor doubled his dose of *Crestor.
He and his wife are concerned about his test results, especially the LDL of 160 mg/dl while taking Crestor.
#1 Will doubling the dose of Crestor have a significant impact on his efforts to get his LDL cholesterol down to 70 mg/dl ?
Answer- doubling the does of Crestor will have minimal effect on his LDL cholesterol.
Have you heard of the rule of 7 ?
Generally the initial dose of a "statin "will lower LDL cholesterol about 30 to 40 % and doubling the statin dose will only add another 7 %. This makes it unlikely that he will reach his target goal of LDL of 70 with Crestor alone.
However he does not have to be perfect to win
He will still have a significant benefit just by taking a "statin".
This was best demonstrated by the Heart Protection Study. This study was done using simvastatin ( Zocor ) in patients with known heart disease or elevated risk of heart disease
The people taking Lipitor benefited with strokes reduced 48% , coronary Bypass graft reduced 31% and acute Myocardial infarcts reduced 36%
Just taking lipitor 10 mg/day Prevented 1 Cardiovascular event /37 pts./1000 treated for 4 years even though 75% of the people in the study failed to achieve the recomended target goal of 70 mg/DL (1.8 mm/L )
Good studies demonstrate that our friend will benefiting by just taking Crestor . However he will probable not gain much from doubling the dose .
What else can he do?Will controlling his blood sugars help control his abnormal lipid problem ?
This discussion will continue tomorrow.
Have fun , be smart , follow your doctors advise and take your Statin
commonly used "Statins"
atorvastatin (Lipitor )
rosuvastatin ( Crestor)
pravastatin ( Pravachol )
lovastatin (mevacor )
When the data was corrected
for other variables , zocor reduced the risk compared to controls by about 1/3 rd. treatment for 5
years will prevent 70 to 100/1000 from having a CV event