Monday, July 9, 2012

Weight Loss- The Other Benefit

Answers- From yesterdays post  ( True or False  Questions)


  #1 GLP-1 agonist is the only diabetes medication that stimulates glucose sensitive insulin release.
                 True _x_       False __



  Comment-
      Glucose sensitive insulin release is one of the best features of GLP-1 agonist. This means that
      insulin is released from the pancreas Beta cells in response to  increasing glucose levels . This effect
      along with restoring the early rapid insulin release restores the Beta cell to a more normal function 
      and reduces the risk of hypoglycemia and preserves Beta cell function.


      Older diabetes medicines ( sulfonynlureas-such as glimepiride , glyburide, glipazide and others)
      cause a continuous insulin release irrespective of meals , increase the risk of hypoglycemia and are
      thought to essentially burn out the Beta cells.


  #2  GLP-1  may be responsible for 50 to 70 % of total insulin secreted after a meal .
                  True _x_       False __

  Comment -          
                               " glucose sensitive insulin release"

             
  #3 People with Type 2 Diabetes have a deficiency of GLP-1.
                    True_x_       False__

  Comment - 
        The exact cause of this deficiency is not clear. Obesity may play a role in the process.


   #4 GPL-1 effectiveness is normal in patients with Type 2 Diabetes.
                     True_x_       False__



    Related article 
                  The other benefit of GLP-1 agonist is weight loss
  Diabetes Care May 12, 2012  vol 35 no. 5 page 955-958
  Baseline factors Associated with glycemic control and weight loss when exenatide ( Byetta )
  was added to optimized insulin Glargine ( Lantus ) in Type 2 Diabetes


 This study was done in obese patients with long standing diabetes 9 to 15 years duration who required insulin for adequate glucose control.  The use of insulin usually results in more weight gain, In this study the group receiving Exenatide plus lantus insulin had greater reduction in their A1c with the added benefit of weight loss compared to the insulin only group.


Have Fun. Be Smart talk to your doctor about some of the newer Diabetes medications
David Calder, MD

6 comments:

  1. The degree of weight loss necessary to achieve health benefits may of course vary among patients. To the obese patient, however, benefits may be measured by a completely non-medical set of personal criteria, such as being able to fit into their clothes.
    IAS

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  2. This effect along with restoring the early rapid insulin release restores the Beta cell to a more normal function and reduces the risk of hypoglycemia and preserves Beta cell function. Online Pharmacy

    ReplyDelete
  3. I think that it is also considered as one of the best diets for weight loss too. You should watch what you eat now.

    ReplyDelete
  4. Since the benefit of this is a fast way to lose fat or an immediate weight loss, is it still safe for them to perform had core work outs such as weight lifting?

    ReplyDelete
  5. Exercise is always a good choice unless their is medical reason to avoid exercise. GLP-1 agonist and DPP-4 inhibitors should not interfere with an exercise program. They both have very low risk of hypoglycemia. Dr. Calder

    ReplyDelete
  6. There are a lot of ways, tips and medication that can be bought online. You should check some online pharmacy review websites for more information.

    ReplyDelete

Your comments and questions are appreciated. David Calder,MD