Saturday, July 7, 2012

DPP-4 a short story continued from yesterday

DPP-4  enzyme system

*DPP-4 ( dipeptidyl peptidase-4 ) is a enzyme in our blood that rapidly degrades GLP-1.

*People with diabetes have a deficiency in GLP-1. 

*Medications that inhibit the DPP-4 enzyme know as DPP-4 inhibitors allows the limited amount   
  of  GPL-1 to remain active and continue its beneficial effects such as increased glucose stimulated 
  insulin release, decreased glucagon secretion and delayed gastric emptying

Brand Names of available DPP-4 inhibitors

 Januvia ( sitagliptin)
 Onglyza ( saxagliptin)
 Tradjenta ( linagliptin )

Questions . ( True or False )
  #1 GLP-1 agonist is the only diabetes medication that stimulates glucose sensitive insulin release.
                 True __       False __

  #2  GLP-1  may be responsible for 50 to 70 % of total insulin secreted after a meal .
                  True __       False __

  #3 People with Type 2 Diabetes have a deficiency of GLP-1.
                    True__       False__

   #4 GPL-1 effectiveness is normal in patients with Type 2 Diabetes.
                     True__       False__

Have Fun , Be Smart Talk to your doctor about GPL-1 Agonist and DPP-4 Inhibitors
David Calder,MD


  1. Here are reviews for some of those select drugs from ph online pharmacy reviews. Some have been OTC according to new provisions.

  2. In a way, this mini-test reminded me of other diabetes drugs. I was thinking of cozaar, but it seems it's not in the listing.

    1. Thanks for your comment. I do not usually think of Cozaar as a diabetes drug. Cozaar is one of the angiotensin receptor blockers available for the treatment of hypertension. Angiotension 2 constricts small arteries resulting in increased blood pressure. Cozaar interfers with angiotensin 2 's attachment to tissue receptors and helps lower blood pressure.
      Dr. Calder


Your comments and questions are appreciated. David Calder,MD