There are a number of markers of inflammation that can be measured and followed by physicians. Today we will focus on one of the common test measured by physicians ,C-Reactive protein (hs CRP ).
C-Reactive Protein is produced in the liver and contains pro - inflammatory and pro-athrogenic
Autopsie studies have found higher levels in the people with acute plague rupture than those with stable atherosclerotic lesions. Higher than normal levels have been found in people with obesity, smokers have a 2 fold higher concentration , metabolic syndrome , Type 2 diabetes, post menopausal women taking hormone replacement therapy and kidney disease.
Cigarette smoking is the strongest environmental stimulus for CRP production.
Daily fluctuations in the test are significant and can be effected by minor things such as viral infection, skin lacerations , and some noninflammatory states ( chronic fatigue, high protein diets, alcohol consumption and depression) . Chronic inflammatory state such as rheumatoid arthrites and lupus may cause false positives. Levels can remain elevated for months following following major infections or other trauma.
Clinically I found this test to be interesting for help in understanding the disease process but of no real clinical benefit in my treatment decisions. I stopped ordering the test .
Tomorrow- More on why I stopped ordering CRP test.
Have fun , Be Smart and learn more about your lab test