Internal Medicine News May 15, 2012
Alternate day dosing Mitigates Statin Muscle Pain by Bruce Jancin
(expert analysis from the annual meeting of the American college of physicians )
The author reviewed 2 articles using rosuvastatin ( Crestor ) but did point out that lipitor ( atorvastatin ) also has a long half life and would also work for alternate day use. The studies were all done on statin intolerant patients.
#1 Alternate day Crestor 5 or 10 mg was studied in 51 patients .
37 ( 73 % ) tolerated the regimen
mean LDL lowering was 34.5 % half of them achieved their target LDL goal
Ann. Pharmacology 2008;42: 341-6
#2 Once-weekly dose 2.5 to 20 mg was studied in 50 previously statin - intolerant patients
base line LDL average 177mg/dl
37 ( 74% ) tolerated the once weekly regimen
The 5 mg group lowered their LDL cholesterol by a mean of 75 mg/dl
The 10 mg group lowered their mean LDL cholesterol by 79mg/dl
clinical ther..2006;28: 933-42
Alternate day doses is another option to consider for patients who are intolerant to Statins.
Muscle problems associated with statins and any dose adjustments of medications need to be discussed and supervised by your physician.
Have fun Be smart , contact your physician if you have muscle complaints associated with Statins.