Tuesday, June 19, 2012

Low -Dose Aspirin and Cancer mortality

Low- Dose aspirin and Cancer mortality: A Meta- Analysis of Randomized Trials
American Journal of Medicine June 2012 , 125 560-567

This study evaluated data from 11 trials reporting cancer mortality in patients taking low -dose aspirin
 ( 75 to 324 mg ). They compared cancer death among patients taking low dose aspirin and non aspirin users.
  Total number of patients -16,066                              
  cancer deaths in patients using aspirin- 162  of 7998 patients  ( 2.02% )
  cancer Deaths in non - aspirin users   -  210 of 8068 patients   ( 2.60 % )

Average followup 2.8 years

These studies demonstrate the effect of low dose aspirin for the prevention of cancer mortality can be realized over a  short  period of time.

They mention another study;
This study reviewed data from 8 different trials and found that aspirin reduced the long term risk of cancer mortality . The effect was observed after only 5 years of observation regardless of aspirin dose or type of cancer.
Rothwell P. et al  Effect of Daily aspirin on long term risk of death due to cancer
Lancet 2011; 377: 31-41


Have Fun , Be  Smart and talk to your doctor about the pros and cons of aspirin use
David Calder, MD

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Your comments and questions are appreciated. David Calder,MD