Normal Vitamin D levels seem to have a positive effect on HDL.
This may be an important association but will require more research to fully evaluate the mechanism and the effect of taking Vitamin D supplements on cardiovascular risk reduction. I have attached portions of two articles that will provide more detail if you are interested. I have high lighted areas of interest to this discussion.
Circulating 25-Hydroxyvitamin D Concentrations Are Correlated With Cardiometabolic Risk Among American Black and White Adolescents Living in a Year-Round Sunny Climate
Samip Parikh MBBS, De-huang Guo MD, Norman K. Pollock PHD, Karen Petty PHD, Jigar Bhagatwala MBBS, Bernard Gutin PHD, Chris Houk MD, Haidong Zhu MD, Yanbin Dong MD
The NHANES 2001–2004 analyses including children and adolescents aged 1 to 21 years showed that 25(OD)D deficiency (<15 ng/mL) was associated with HDL cholesterol levels as compared with 25(OH)D levels ≥30 ng/mL (6). The assay-adjusted 25(OH)D data from NHANES 2001–2006 in adolescents aged 12–19 years found that 25(OH)D was directly related to HDL cholesterol (7). In addition, Rajakumar et al. (28) reported that in 237 black and white children (mean ± SD: 12.7 ± 2.2 years), plasma 25(OH)D was positively associated with HDL cholesterol. In theory, vitamin D could affect lipid levels directly, e.g., vitamin D is thought to be essential for maintaining adequate levels of apolipoprotein A-I, a major component of HDL cholesterol (29,30). In addition, the indirect effects of vitamin D on lipids could be through PTH or calcium balance. Furthermore, vitamin D might improve insulin secretion and insulin sensitivity, thereby indirectly influencing lipid metabolism (31). Our results demonstrated that 25(OH)D was positively correlated with HDL cholesterol independent of adiposity (i.e., %BF), which requires carefully controlled interventional and other experimental studies to further understand the observation.
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