Wednesday, May 16, 2012

" Importantly. islet cell dysfunction is not necessarily irreversible

 Management of Hyperglycemia in Type 2 Diabetes: A Patient Centered Approach
Position statement of the American Diabetes Association and the European Association for the study of Diabetes
April 2012

Page 2
 "Overview of the pathogenesis of type 2 diabetes"
  The first paragraph points out that a rise in blood sugar is the result of glucose influx exceeding glucose outflow. 
They point out that abnormal islet cell function is a feature of the 2 diabetes.
 "The functional islet cell incompetence is the main quantitative determinant of hyperglycemia  and 
   progresses over time "

                       " Importantly , islet cell dysfunction is not necessarily irreversible " 

 They recognize the value of weight loss , including bariatric surgery , in decreasing insulin resistance 
  and relieving the secretory burden of the Beta cells.

 They  also mention the role of  the dysfunctional  Alpha cells hyper-secreting glucagon resulting  in
  increased inappropriate glucose release from the liver 

Reading page 2 reminds me of one of the best things physicians can offer their patients is , Hope. 
 " Importantly , islet cell dysfunction is not necessarily irreversible " , provides that little glimmer of hope.

Have fun , Be Smart and thank God for the wonderful medical research
David Calder,MD

 Check out 2 related post from the past 
                                           Oct 8,2011  Lessons from my first patient , Hope
                                           Feb 12 , 2012 Glucagon effects your everyday life

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Your comments and questions are appreciated. David Calder,MD