What are ACE inhibitors and ARBS . These medications work in different ways to reduce the effect of angiotension 2 on our blood pressure.
The enzymes and the receptor blockers
ACE ( angiotension converting enzyme ) - converts Angiotensin 1 to Angiotension 2
Angiotensin- 2 - a very potent constrictor of small arteries increasing blood pressure
ACE inhibitors - partially blocks angiotension converting enzyme and allows dilation of small arteries
lowering blood pressure . (see yesterdays blog for a list of ACE Inhibitors)
Angiotensin -2 Receptor - angiotensin 2 has to connect into a receptor on our arteries
to effectively raise blood pressure
ARBS ( angiotensin receptor blockers ) - lowers blood pressure by interfering with the ability of
angiotensin 2 to connect to small arteries .
List of Angiotensin receptor blockers
losartan ( Cozaar )
valasartan ( Diovan)
irbesartan ( Avapro )
candesartan ( Atacand )
azilsartan ( Edarbi )
eprostartan ( Teveten )
olmesartan ( Benicar )
telmisartan ( Micardis )
We started this conversation discussing 2 cases of an unusual complication of ACE inhibitors , Angioedema.
Can a person who has had angioedema with ACE inhibitors take a ARB ?
The answer tomorrow.
Have fun, be Smart , be Safe - understand more about your blood pressure pills
David Calder, MD