Friday, April 20, 2012

Your Blood Pressure - Angioedema - ACES and ARBS

 What are ACE inhibitors and ARBS . These medications work in different ways to reduce  the effect of angiotension 2  on our blood pressure.

The enzymes and the receptor blockers

ACE ( angiotension converting enzyme ) - converts Angiotensin 1 to Angiotension 2

Angiotensin- 2 -   a very potent constrictor of small arteries increasing blood pressure

ACE inhibitors - partially blocks angiotension converting enzyme and allows dilation of small arteries
                             lowering blood pressure . (see yesterdays blog for a list of ACE Inhibitors)

 Angiotensin -2 Receptor   - angiotensin 2 has to connect into a receptor on our arteries 
                                               to effectively raise blood pressure

ARBS ( angiotensin receptor blockers ) -   lowers blood pressure by interfering with the ability of 
                                                                    angiotensin 2 to connect to small arteries .

List of Angiotensin receptor blockers
losartan       ( Cozaar ) 
valasartan   ( Diovan)
irbesartan    ( Avapro )
candesartan ( Atacand )
azilsartan      ( Edarbi )
eprostartan   ( Teveten )
olmesartan    ( Benicar )
telmisartan    ( Micardis )

We started this conversation discussing 2 cases of an unusual complication of ACE inhibitors , Angioedema. 
Can a person who has had angioedema with ACE inhibitors take a ARB ?

The answer tomorrow. 

Have fun, be Smart , be Safe - understand  more about your blood pressure pills
David Calder, MD



  1. Thanks for sharing this list of Angiotensin receptor blockers. I think it's great to have them listed just in case of emergency medications. nasonex prices


Your comments and questions are appreciated. David Calder,MD