The cause of the angioedema was lisinopril.
Angioedema is a transient swelling of subcutaneous tissue with multiple triggers that can be;
Allergies - such as food allergies ( nuts , shell fish , eggs ) , medications (penicillin sulfa and others )
insect bites and latex are common
Non - Allergic Drug Reaction - ACE Inhibitors
I would like to focus our attention on the Non- Allergic drug reactions seen with medications called
ACE Inhibitors . Lisinopril is a ACE inhibitor and was taken by both of the patients discussed
ACE inhibitors are excellent safe medications used by millions of people with diabetes to treat high
blood pressure and to help protect their kidneys from the damage caused by diabetes.
The Symptoms , are unusual atypical mimics
The symptoms of ACE Inhibitor induced angioedema are atypical and mimic other more common problems such insect bites , hives , heart and gall bladder disease.
There are a few symptoms are more specific to angioedema.
#1 the symptoms usually occur on one side of our body and resolve in hours to days with no residual
Our patient number 2 had recurrent swelling and itching of either the top of his right or left foot
and numbness swelling and tingling of the left side of his tongue
#2 atypical chest or upper abdominal pain with abnormal liver test that return to normal within a few
A physician friend of mine had one patient develop severe angiedema of her throat after taking
her first pill . Our patients # 1 and 2 developed symptoms after years of taking lisinopril.
#4 There may be a family history of allergies to medications.
Our patients #1 is allergic to Dilantin,and has a son and daughter allergic to penicillin.
Our patient #2 is allergic to penicillin , has hay fever and mild asthma and has a son allergic to
latex and penicillinA.
ACE Inhibitors are common very useful medications
Lisinopril ( prinivil , Zesteril )
Captopril (capiton )
Ramipril (Altase )
Enalapril ( Vasotec enalaprilat )
Quinipril ( Accupril )
Benazepril ( Lotensin )
cilazapril (Inhibace )
fosinopril ( monopril )
moexipril (Univasc )
perindopril ( Aceon , Coversyl )
Trandolapril ( Mavik )
It is hard to remember all of these different brands . Did you notice the generic names all end in "pril "
Have fun , be smart and understand the medication the medicines you are taking
David Calder , MD
Tomorrow! What about them ARBS and are they related to ACE.