The article abstract below from PubMed provides more reasons for choosing once -weekly exenatide. The once weekly Exenatide( Byetta) in various combination with metformin and sulfonylureas had less hypoglycemia , more weight loss and equivalent A1c reduction .
Exenatide once weekly decreased 1.3 decreased 2.1 kg( 4.6 pounds )
Lantus insulin decreased 1. 0 increased 2,4 kg (5.2 pounds)
Hypoglycemia (mild )
Exenatide plus metformin 8%
Exenatide/metformin/ sulfonylurea 24%
Lantus insulin plus metformim 32%
Lantus insulin/ metformin / sulfonylurea 54%
Comment - this article adds more support to the idea of retiring sulfonylureas and supports the use of Exenatide ( Byetta) once weekly and metformin (glucophage ) as the best choice of medications for someone with type 2 diabetes .
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