NMR lipid profile is a test that measures the number and size of lipoproteins such as LDL and HDL. This can be useful when trying to evaluate someones LDL cholesterol when they have an elevation of their Triglyceride level over 150mg/dl.
LDL is made in the liver and is produced is a spectrum of sizes varying from small to large LDL particles. The smaller size LDL is associated with increased risk of heart disease . Triglyceride elevation which is common in people with Type 2 diabetes is associated with an increase is the small dense LDL particles .
Apo b test is another way of this problem. See my blog Dec.14
What are the Benefits of A1c testing ?
This is a great question.
Glucose in blood binds to hemoglobin in red blood cells and remains attached for the life of the cell which is about 3 months. Higher glucose levels are associated with more glucose attachment . The chart below will give you an idea of how A1c results correlate with mean glucose test results..
Mean plasma glucose
6 126 7.0
7 154 8.6
8 183 10.2
9 212 11.8
10 240 13.4
11 269 14.9
The A1c test is a predictor of the risk for developing diabetes complications. Two classic studies, the DCCT study in Type 1 Diabetes and the UKPDS done with Type 2 Diabetes demonstrated a significant reduction in eye , nerve and kidney damage by reducing the A1c to 7. There was about a 30 % reduction in risk for a 1 % point drop in A1c. There was also a nonsignificant 16% reduction in cardiovascular risk by reducing The A1c from 8 to 7 in the UKPDS .
These two large studies and another one called the Kumamoto study provided the evidence for establishing an A1c result of < 7 as the recommended target goal
Thanks again for the good question. Dr. Calder